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Episodes
The Human Upgrade: Biohacking for Longevity & PerformanceEpisode 15331:09:00Everything You Need To Know About Your Poop | Gut Surgeon Explains : 1533
Dave Asprey and Dr. Karan Rajan dive deep into gut health, covering fiber science, fermentation, sodium myths, and the weirdest things a GI surgeon has ever removed from a patient.
Huberman LabEpisode 2977426 minHow Mitochondria Control Your Metabolism | Dr. Jared Rutter
Dr. Jared Rutter, PhD, Professor of Biochemistry at the University of Utah and Howard Hughes Medical Institute Investigator, is a leading expert on mitochondria and metabolism. He explains how mitochondria produce the energy for your cells to work but also how they regulate cell growth and replication and thereby contribute to health and disease. We also discuss how mitochondria are linked to aging, cancer, and other diseases. Our conversation explores your metabolism as the composite of trillions of individual cells and points to new ways to improve health, avoid, and treat diseases. Show notes: https://go.hubermanlab.com/297-jared-rutter Pre-order Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Jared Rutter (00:02:29) Metabolism, Cells; Aging (00:08:36) Mitochondria, Origin & Cell Complexity (00:13:07) Sponsors: Joovv & BetterHelp (00:15:16) Mitochondria Genome, Inheritance (00:18:18) Mitochondria & Spatial Distribution; Cell-Specific Metabolism (00:25:59) Nutrient Energy, Hormones, Fat Cells (00:31:13) Glucose, ATP Conversion, Pyruvate (00:36:41) Cell Choice: Energy or Growth, Cancer; Virus (00:46:02) Sponsors: AG1 & Eight Sleep (00:48:36) Microbiome, Role of Humans (00:51:44) Molecule Discovery Process, MPC1, MPC2 (00:59:42) Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart (01:07:03) Cell Resource Allocation, MPC, Heart Failure; Disease (01:11:46) Sponsor: Function (01:13:24) Cell Size vs Fuel Balance, Cell Identity & Disease (01:20:43) MPC Discovery, Genetics, Model Systems (01:24:29) Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy (01:31:32) Cancer, Mutations, Metabolism Changes & Warburg Effect (01:36:18) Cancer Challenges & Therapies (01:43:00) Therapy Combinations, Unique Cancer Mutations & Metabolism (01:48:31) Technology to Visualize Metabolism; Disease, Metabolism & Scents (01:56:34) Excess Energy & Mitochondria, Reactive Oxygen Species (02:01:12) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
The Peter Attia Drive1:16:50Blood pressure: how to measure, manage, and treat high blood pressure (AMA #48 rebroadcast)
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter delves into the critical subject of blood pressure, which is one of the three primary causes of atherosclerosis, along wi
The Human Upgrade: Biohacking for Longevity & PerformanceEpisode 15320:10:03If I Had To Lose 50 Pounds FAST, I’d Do THIS : 1532
Dave Asprey breaks down three science-backed rules — cutting ultra-processed food, adopting adequate fasting windows, and redesigning your environment — to lower insulin resistance and break the metabolic block that's stalling your fat loss.
Boundless Life3599 minHow To Build An Ideal Workday With Power Naps, Email Delegation & Deep Work Tactics, Featuring Chandler Bolt
Full show notes: bengreenfieldlife.com/bolt In this episode, Chandler Bolt and I talk about how we've each landed on almost identical daily systems for running a company, and the one place we still disagree. Chandler makes the case that a book is a business asset rather than an income stream, explai
The Tim Ferriss ShowEpisode 8811:05:23#881: Tales of Overcoming The Odds, and How to Turn Losses Into Wins — Tim McGraw, Terry Crews, Dax Shepard, and More
This is a special episode about overcoming mistakes and failure. What do you do when your work is rejected, when the big bet fails, or when the path ahead suddenly disappears? As you’ll hear in this episode, setbacks can often present opportunities, if you know how to look for them.This episode is brought to you by:Helix Sleep premium mattresses: HelixSleep.com/Tim (20% off any purchase)Gusto simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: Gusto.com/TimIncogni, which removes your personal data from the web, helping shield you from fraud, scams, and identity theft: Incogni.com/Tim (use code TIM at checkout and get 60% off an annual plan)In this episode: BJ Miller, a triple amputee, on his years-long quest to ride a motorcycle.Terry Crews on missing a season-ending shot—and the mindset shift that stayed with him for life.Tim McGraw on his debut album flopping and betting his career on next steps.Jessica Lahey on being told her first book was “unpublishable” and turning brutal feedback into a New York Times bestseller.Dax Shepard on the collapse of an identity and career he thought he wanted—and the unexpected much better life it made possible.Cathy Lanier on becoming a teenage single mother, passing her GED by a single point, and beginning an unlikely climb.Janna Levin on the liberating realization that life is not a smooth path interrupted by obstacles—life is the obstacles.Boyd Varty on using the mindset of a lion tracker to move through uncertainty and the paralysis of not knowing what comes next.Dr. BJ Miller is a triple amputee, longtime palliative-care physician, cofounder of virtual palliative-care service Mettle Health, and coauthor of A Beginner’s Guide to the End.Terry Crews is an actor, artist, author, television host, and former NFL player best known as Terry Jeffords on the Emmy-nominated TV series Brooklyn Nine-Nine and as the longtime host of America’s Got Talent.Tim McGraw is a three-time Grammy-winning country-music superstar, an actor, and a 2026 Country Music Hall of Fame inductee.Jessica Lahey is an educator and the New York Times bestselling author of The Gift of Failure and The Addiction Inoculation.Dax Shepard is an actor, writer, and director and the co-creator and host of the hit podcast Armchair Expert.Cathy Lanier is the NFL’s chief security officer and the first woman—and longest serving chief—to lead Washington, DC’s Metropolitan Police Department.Janna Levin is a theoretical cosmologist, the Claire Tow Professor of Physics and Astronomy at Barnard College, a Guggenheim Fellow, a PEN-winning author, and the founding director of sciences at Pioneer Works.Boyd Varty is a lion tracker, wildlife activist, TED speaker, and author of The Lion Tracker’s Guide to Life.Timestamps:00:00 — Introduction from Tim01:23 — BJ Miller: Making an Impossible Motorcycle Dream Real05:35 — Terry Crews: Why You Have to Take the Shot16:28 — Tim McGraw: Failing on Your Own Terms27:31 — Jessica Lahey: From “Unpublishable” to Bestseller31:48 — Dax Shepard: When Failure Saves You From What You Want38:11 — Cathy Lanier: Rebuilding a Life47:33 — Janna Levin: Life Is the Obstacles54:36 — Boyd Varty: Finding the Next Track When You’re Stuck*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferriss See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
The Human Upgrade: Biohacking for Longevity & PerformanceEpisode 15310:07:48Raw Garlic, Egg Yolks, Heat Strokes, and Melatonin : 1531
This episode debunks some viral raw garlic claims and reviews new research on HEPA filtration, egg yolk peptides, heatstroke's long-term health risks, and melatonin's link to heart failure — closing with a reminder to control how much stress you put your body through.
Boundless Life3352 minHow to Replace Sauna, Fasting, and Cold Plunge With a Pill (WARNING: Proceed at Your Own Risk!) With Dr. Sandra Kaufmann
Full show notes: bengreenfieldlife.com/pharma In this special repeat episode, Dr. Sandra Kaufmann breaks down which pharmaceuticals mimic the effects of things you already do for your health: what replaces a sauna session, what replaces a fast, what replaces a cold plunge (use code BENFORGE for $500
Longevity Optimization with Kayla Barnes-Lentz1:17:23Dr. Tania Dempsey, MD: Mast Cell Activation Syndrome, PMOS, and the Hidden Cause of Women's Chronic Symptoms
Most women who deal with unexplained allergies, stubborn inflammation, heavy periods or a PMOS (formerly PCOS) diagnosis are never told to look at the same underlying cause: an immune cell most doctors were never taught to test for. Dr. Tania Dempsey, MD, trained in internal medicine at Johns Hopkins before leaving conventional practice to focus on mast cell activation syndrome, a condition she believes explains far more chronic illness in women than most doctors realize. She's the founder of The AIM Center for Personalized Medicine and helped found the International Society for Mast Cell Activation Syndromes, where she now serves as treasurer. This isn't some rare, fringe diagnosis. Dr. Dempsey estimates it may affect as many as one in five people, and in women it hides behind a long list of other labels, PMOS, endometriosis, hypermobility, unexplained heavy periods, that rarely get connected back to the same root. Optimize your sleep with the Eight Sleep Pod. Get up to $350 off at https://www.eightsleep.com/Kayla with code “ KAYLA ”. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community This conversation explores The overreaction inside your immune system that never fully resets Why PMOS and mast cell activation almost always show up together The natural blood thinner behind unusually heavy periods Where treatment actually starts, from vitamin D to advanced IV therapy Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Connect with Dr. Tania Dempsey: Instagram: https://www.instagram.com/drtaniadempseymd/ LinkedIn: https://www.linkedin.com/in/taniadempsey/ Website: https://drtaniadempsey.com/ YouTube: https://www.youtube.com/@DrTaniaDempsey #longevity #womenslongevity #mastcellactivationsyndrome #mcas #pmos #histamineintolerance #endometriosis #womenshealth #chronicillness #rootcausemedicine #hormonehealth #inflammation
The Human Upgrade: Biohacking for Longevity & PerformanceEpisode 15301:58:16Jenny McCarthy | The 3 Questions You’re NEVER Supposed to Ask : 1530
Jenny McCarthy Wahlberg joins Dave Asprey to trace her son's autism diagnosis back to a vaccine reaction and share the detox, gut-healing, and biohacking protocol that reversed it, then dives into peptides, hormone therapy, and longevity strategies for adults.
Huberman Lab2051 minEssentials: Use Sleep to Enhance Learning, Memory & Emotional State | Dr. Gina Poe
In this Huberman Lab Essentials episode, my guest is Dr. Gina Poe, PhD, a Professor of Integrative Biology and Physiology at the University of California, Los Angeles (UCLA). We discuss the architecture of sleep and how each stage supports distinct functions, including memory consolidation, creativity, brain restoration, and emotional processing. We also explain science-supported tools to improve sleep quality, support cognitive performance, and hormone balance. Show notes: https://go.hubermanlab.com/Y6JKgFE Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (00:00:00) Gina Poe (00:00:19) Sleep States, Perfect Night's Sleep (00:02:23) Early Sleep, Memory Processing, Dreams (00:04:34) Growth Hormone & Early Sleep, Tool: Consistent Bedtime (00:06:47) Sponsor: LMNT (00:08:20) Alcohol & Negative Sleep Effects (00:09:18) Middle Sleep States, Creativity (00:10:32) Waking During Night, Nighttime Urination (00:11:39) Later Sleep, REM, Deep Sleep; Sleepwalking (00:14:01) Morning Grogginess; Sleep Trackers (00:15:53) Early Sleep "Washout", Brain Waste Clearance (00:19:56) Sponsor: Eight Sleep (00:21:14) Locus Coeruleus, Learning & REM Sleep, Tool: Calm Bedtime Routine (00:25:16) Sleep Spindles, P Waves, Learning & Creativity (00:28:38) Sponsor: AG1 (00:29:56) Trauma Recovery, REM Sleep, Locus Coeruleus (00:33:29) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
The Human Upgrade: Biohacking for Longevity & PerformanceEpisode 15290:35:543 Longevity Drugs I QUIT (And the 4 I Take Instead) : 1529
Dave Asprey breaks down why metformin, rapamycin, and statins fall short as longevity drugs, and makes the case for tadalafil, SGLT2 inhibitors, acarbose, and low dose naltrexone instead.